What the label states, the lot delivers — net peptide mass, not gross powder weight, purity reported as measured rather than rounded up, and a Certificate of Analysis for every lot.
Net peptide mass, not powder weight; purity as measured, not rounded up; a COA per lot.
Net peptide + purity not rounded up. COA per lot.
FDA PCAC reviews 7 peptides for the 503A bulks list (BPC-157, KPV, TB-500, MOTs-C, Emideltide, Semax, Epitalon). Read our compounder's decision tree. Read our briefing →
FDA PCAC reviews 7 peptides for the 503A bulks list in July. Read →
FDA PCAC: 7 peptides under review. Read →
Mitochondrial-derived 24-mer cytoprotective peptide
Overview
Humanin (HN) was the first identified mitochondrial-derived peptide (MDP), encoded by a small open reading frame within the mitochondrial DNA 16S rRNA gene (MT-RNR2) rather than the nuclear genome. It was first reported by Hashimoto et al. in 2001 (PNAS 98:6336), identified while screening an Alzheimer's disease patient occipital-lobe cDNA expression library for factors that could antagonize neuronal apoptosis induced by mutant APP (V642I). Vialdyne releases Humanin as a lyophilized peptide against a ≥98% HPLC main-peak specification, supplied with a batch-specific Certificate of Analysis covering RP-HPLC purity, mass-spec identity, appearance, and water content. Lots are released only after the COA is on file.
Applications & buyer fit
Mitochondrial-targeted peptides ship primarily to research labs studying OXPHOS, ROS biology, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes these peptides somewhat oxidation-prone in solution, working stocks should be prepared fresh or held at -80 °C rather than -20 °C when the workflow permits.
Sourced for
Buyer fit
Documentation that ships
Procurement note: The cationic / lipophilic character makes these peptides oxidation-prone in solution; working stocks are best held cold and prepared fresh.
Primary buyer fit: academic and contract research laboratories.
Specifications
Certificate of Analysis
Published released-batch COAs for Humanin, every lot HPLC-verified. These are previews — request the full high-resolution certificate for any lot.
Browse all published COAsRegulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
Humanin ships as white to off-white lyophilized powder with a batch-specific Certificate of Analysis reporting RP-HPLC purity (≥98%), mass-spec identity and sequence MAPRGFSCLLLLTSEIDLPVKRRA, and appearance. Recommended storage: -20°C, desiccated. Supplied strictly as a research reference material — not for human or veterinary use.
Related peptides
16-mer
Mitochondrial-derived peptide
15-mer
Mitochondria-targeted tetrapeptide (Szeto-Schiller)
Redox coenzyme for cellular-energy research
