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Mitochondria-targeted tetrapeptide (Szeto-Schiller)
Overview
SS-31, also known as Elamipretide (MTP-131, Bendavia), is a cell-permeable Szeto-Schiller tetrapeptide that concentrates selectively in the inner mitochondrial membrane through reversible association with cardiolipin. By stabilising cardiolipin-cytochrome-c interactions it is studied for its effect on electron-transport-chain efficiency and reactive-oxygen-species generation, which is why mitochondrial, cardiac, and neurodegeneration research models are the dominant demand context. Vialdyne releases lyophilised SS-31 acetate at ≥99.0% HPLC main-peak, with a batch COA covering RP-HPLC purity, peptide-content assay, related substances, water (Karl Fischer), counter-ion, residual solvents, and endotoxin. ESI-MS identity and the raw chromatogram are documented on the same lot for labs assembling a CMC or reference-standard dossier.
Applications & buyer fit
Mitochondrial-targeted peptides ship primarily to research labs studying OXPHOS, ROS biology, and mitochondrial dysfunction in disease models. The lipophilic / cationic character that drives mitochondrial accumulation also makes these peptides somewhat oxidation-prone in solution, working stocks should be prepared fresh or held at -80 °C rather than -20 °C when the workflow permits.
Sourced for
Buyer fit
Documentation that ships
Procurement note: The cationic / lipophilic character makes these peptides oxidation-prone in solution; working stocks are best held cold and prepared fresh.
Primary buyer fit: academic and contract research laboratories.
Specifications
Certificate of Analysis
Published released-batch COAs for SS-31 (Elamipretide), every lot HPLC-verified. These are previews — request the full high-resolution certificate for any lot.
VerifiedRequest full COA →SS-31 (Elamipretide)
VD260301005 · 99.72%
VerifiedRequest full COA →SS-31 (Elamipretide)
VD260301013
Regulatory note
Investigational compound; not approved as a finished drug in any jurisdiction. Sold as a research-use-only reference material, not for human or veterinary use.
Frequently asked questions
SS-31 carries an alternating aromatic-cationic motif (the Szeto-Schiller design) that lets the peptide cross the plasma membrane and then concentrate in the inner mitochondrial membrane through reversible binding to cardiolipin, a phospholipid unique to that membrane. This targeting is what separates SS-31 from peptides that act at the cell surface, and it is the basis for its use in mitochondrial-bioenergetics research.
Yes. SS-31 is the original Szeto-Schiller laboratory designation; Elamipretide (MTP-131) is the international nonproprietary name used in clinical development, and Bendavia is a former development code. All refer to the same D-Arg-Dmt-Lys-Phe-NH2 tetrapeptide (Dmt = 2,6-dimethyltyrosine). The released-batch COA lists CAS 736992-21-5 and the ESI-MS identity so the molecule can be cross-referenced unambiguously.
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