SNAP-8

Overview

SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide studied as a topical cosmetic active and an extension of the acetyl-hexapeptide (Argireline) concept. Its sequence mimics the N-terminal domain of the SNAP-25 protein, and in cosmetic-peptide research it is investigated as a SNARE-competitive modulator of acetylcholine release at the neuromuscular junction. It is supplied strictly as a research reference material. Vialdyne releases SNAP-8 as a lyophilized peptide against a ≥99.0% HPLC main-peak specification, supplied with a batch-specific Certificate of Analysis covering RP-HPLC purity, mass-spec identity, appearance, and water content. Lots are released only after the COA is on file.

Applications & buyer fit

Cosmetic-peptide buyers fall into two groups: established beauty / med-aesthetic brands extending an existing line, and OEM clients building a private-label catalog from scratch. The first group usually wants active material plus stability data in their existing carrier matrix; the second usually wants a finished formulation under their label. Both need INCI naming verified, regulator-specific safety files (CPNP for EU, FDA OTC monograph for US where relevant), and packaging-compatibility data.

Primary buyer fit: academic and contract research laboratories.

Specifications

CAS

868844-74-0

Molecular Formula

C41H70N16O16S

Molecular Weight

1075.2 Da

Sequence

Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2

Appearance

White to off-white lyophilized powder

Purity (HPLC)

≥ 99.0%

Strength

10 mg – 100 mg

Packaging

10 vials/box · base pack (multiples of 10)

Half-life

≈ 4-6 hour

MOQ

On request

Lead time

10–18 days

Storage

2–8°C, protect from light

Certificate of Analysis

Representative COA previews for SNAP-8; request the certificate matched to the offered or supplied lot from sales. These are previews — request the full high-resolution certificate for any lot.

VerifiedRequest full COA →

Snap-8

VD260428-NP8188 · 99.25%

VerifiedRequest full COA →

Snap-8

VD260428-NP8187 · 98.95%

Independent analytical testing

Product- and strength-matched first-page previews are shown separately from Vialdyne's lot-specific Batch COAs. Reference the report number when requesting the complete, high-resolution file from sales.

Third-party testView report record →

SNAP-8

10 mg · HPLC / MS

NP810-20260810S6595

Regulatory note

Research-use-only reference material; not for human or veterinary use.

Selected literature

1. Shin JY, Han D, Yoon KY, Jeong DH, Park YI. Clinical safety and efficacy evaluation of a dissolving microneedle patch having dual anti-wrinkle effects with safe and long-term activities. Ann Dermatol. 2024;36(4):215-224.
2. Avcil M, Akman G, Klokkers J, Jeong D, Çelik A. Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. J Cosmet Dermatol. 2020;19(2):328-337.
3. Pintea A, Manea A, Pintea C, Vlad RA, Bîrsan M, Antonoaea P, Rédai EM, Ciurba A. Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review. Biomolecules. 2025;15(1):88.
4. Blanes-Mira C, Merino JM, Valera E, Fernández-Ballester G, Gutiérrez LM, Viniegra S, Pérez-Payá E, Ferrer-Montiel A. Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis. J Neurochem. 2004;88(1):124-135.
5. Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310.

Frequently asked questions