What the label states, the lot delivers — net peptide mass, not gross powder weight, purity reported as measured rather than rounded up, and a Certificate of Analysis for every lot.
Net peptide mass, not powder weight; purity as measured, not rounded up; a COA per lot.
Net peptide + purity not rounded up. COA per lot.
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Spadin-derived TREK-1 heptapeptide · neuro research
Overview
PE-22-28 (also known as Mini-Spadin) is a synthetic seven-amino-acid fragment corresponding to residues 22-28 of the parent peptide spadin, with the sequence Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR). Spadin itself is derived from a propeptide fragment released during maturation of sortilin (NTSR3) — a 17-amino-acid fragment corresponding to residues 12-28 of the propeptide, designated PE 12-28. Vialdyne releases PE-22-28 as a lyophilized peptide against a ≥98% HPLC main-peak specification, supplied with a batch-specific Certificate of Analysis covering RP-HPLC purity, mass-spec identity, appearance, and water content. Lots are released only after the COA is on file.
Applications & buyer fit
Cognitive and neuropeptide buyers are predominantly research labs running in vivo rodent studies. The dominant administration route in the literature is intranasal, these peptides are not meaningfully blood-brain-barrier permeable when delivered systemically. For in vivo workflows, endotoxin and microbial-limit testing is recommended at the COA stage so the bioassay readout is not confounded by contamination unrelated to the test article.
Sourced for
Buyer fit
Documentation that ships
Procurement note: For in vivo workflows, endotoxin and microbial-limit testing on the specific lot is recommended at the COA stage.
Primary buyer fit: academic and contract research laboratories.
Specifications
Certificate of Analysis
Published released-batch COAs for PE-22-28, every lot HPLC-verified. These are previews — request the full high-resolution certificate for any lot.
VerifiedRequest full COA →PE-22-28
VD260428-PE154 · 99.48%
VerifiedRequest full COA →PE-22-28
VD260428-PE153 · 98.87%
Regulatory note
Research-use-only reference material; not for human or veterinary use.
Selected literature
Frequently asked questions
PE-22-28 ships as white to off-white lyophilized powder with a batch-specific Certificate of Analysis reporting RP-HPLC purity (≥98%), mass-spec identity and sequence Gly-Val-Ser-Trp-Gly-Leu-Arg, and appearance. Recommended storage: -20°C, desiccated. Supplied strictly as a research reference material — not for human or veterinary use.
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