FDA PCAC reviews 7 peptides for the 503A bulks list (BPC-157, KPV, TB-500, MOTs-C, Emideltide, Semax, Epitalon). Read our compounder's decision tree. Read our briefing →
FDA PCAC reviews 7 peptides for the 503A bulks list in July. Read →
FDA PCAC: 7 peptides under review. Read →
Pineal tetrapeptide · telomere research
Overview
Epitalon (also spelled Epithalon) is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, modelled on the active fragment of the pineal polypeptide preparation Epithalamin characterised by Khavinson. It is one of the most-cited longevity research peptides, studied for its reported effects on telomerase expression, telomere maintenance, and circadian/melatonin regulation in cell and animal models. Vialdyne releases lyophilised Epitalon at ≥99.0% HPLC main-peak, with a batch COA covering RP-HPLC purity, peptide-content assay, related substances, water (Karl Fischer), acetic-acid counter-ion, residual solvents, and endotoxin. Sequence and ESI-MS identity are documented on the same lot for reference-standard qualification.
Applications & buyer fit
Buyers for longevity-class peptides span research labs working on telomere, collagen, and circadian-rhythm models, plus cosmetic-formulation OEMs incorporating peptides like GHK-Cu into anti-aging finished products. Copper peptides in particular require attention to chelator-free water and EDTA-free buffers in downstream formulation work, incompatibility there is the most common cause of "the peptide didn't work" support tickets in this class.
Sourced for
Buyer fit
Documentation that ships
Procurement note: Copper peptides require chelator-free water and EDTA-free buffers in downstream formulation work.
Primary buyer fit: academic and contract research laboratories.
Specifications
Certificate of Analysis
Published released-batch COAs for Epitalon (Epithalon), every lot HPLC-verified. These are previews — request the full high-resolution certificate for any lot.
Browse all published COAsRegulatory note
Research-use-only reference material; not an approved drug in the US or EU. Not for human or veterinary use.
Frequently asked questions
Yes, they are two transliterations of the same synthetic tetrapeptide, Ala-Glu-Asp-Gly (CAS 307297-39-8). It is the short synthetic peptide modelled on Epithalamin, the natural pineal polypeptide complex studied by Khavinson and colleagues. The COA lists the sequence and ESI-MS identity so spelling differences across suppliers can be reconciled to one molecule.
Research interest centres on reports that Epitalon can induce telomerase activity and support telomere maintenance in somatic cells, alongside effects on melatonin and circadian regulation attributed to its pineal origin. These are research findings in cell and animal models; Vialdyne supplies the peptide strictly as a research reference material and makes no therapeutic claim.
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